ASTHMA GENETICS, GENOMICS, AND ENDOTYPING 

 

Dissecting childhood asthma with nasal transcriptomics distinguishes subphenotypes of disease

Poole A, Urbanek C, Eng C, Schageman J, Jacobson S, O'Connor BP, Galanter JM, Gignoux CR, Roth LA, Kumar R, Lutz S, Liu AH, Fingerlin TE, Setterquist RA, Burchard EG, Rodriguez-Santana J, Seibold MA.

J Allergy Clin Immunol. 2014 Mar;133(3):670-8

IL1RL1 asthma risk variants regulate airway type 2 inflammation

Gordon ED, Palandra J, Wesolowska-Andersen A, Ringel L, Rios CL, Lachowicz-Scroggins ME, Sharp LZ, Everman JL, MacLeod HJ, Lee JW, Mason RJ, Matthay MA, Sheldon RT, Peters MC, Nocka KH, Fahy JV, Seibold MA.

JCI Insight. 2016 Sep 8;1(14)

Alternative splicing of interleukin-33 and type 2 inflammation in asthma

Gordon ED, Simpson LJ, Rios CL, Ringel L, Lachowicz-Scroggins ME, Peters MC, Wesolowska-Andersen A, Gonzalez JR, MacLeod HJ, Christian LS, Yuan S, Barry L, Woodruff PG, Ansel KM, Nocka K, Seibold MA, Fahy JV.

Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8765-70.

Whole Genome Sequencing of Pharmacogenetic Drug Response in Racially Diverse Children with Asthma

Mak AC, White MJ, Eckalbar WL, Szpiech ZA, Oh SS, Pino-Yanes M, Hu D, Goddard P, Huntsman S, Galanter J, Wu AC, Himes BE, Germer S, Vogel JM, Bunting KL, Eng C, Salazar S, Keys KL, Liberto J, Nuckton TJ, Nguyen TA, Torgerson DG, Kwok PY, Levin AM, Celedón JC, Forno E, Hakonarson H, Sleiman PM, Dahlin A, Tantisira KG, Weiss ST, Serebrisky D, Brigino-Buenaventura E, Farber HJ, Meade K, Lenoir MA, Avila PC, Sen S, Thyne SM, Rodriguez-Cintron W, Winkler CA, Moreno-Estrada A, Sandoval K, Rodriguez-Santana JR, Kumar R, Williams LK, Ahituv N, Ziv E, Seibold MA, Darnell RB, Zaitlen N, Hernandez RD, Burchard EG; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium.

Am J Respir Crit Care Med. 2018 Mar 6. doi: 10.1164/rccm.201712-2529OC. [Epub ahead of print]

ROP: dumpster diving in RNA-sequencing to find the source of 1 trillion reads across diverse adult human tissues

Mangul S, Yang HT, Strauli N, Gruhl F, Porath HT, Hsieh K, Chen L, Daley T, Christenson S, Wesolowska-Andersen A, Spreafico R, Rios C, Eng C, Smith AD, Hernandez RD, Ophoff RA, Santana JR, Levanon EY, Woodruff PG, Burchard E, Seibold MA, Shifman S, Eskin E, Zaitlen N.

Genome Biol. 2018 Feb 15;19(1):36. doi: 10.1186/s13059-018-1403-7.

The landscape of genomic imprinting across diverse adult human tissues

Baran Y, Subramaniam M, Biton A, Tukiainen T, Tsang EK, Rivas MA, Pirinen M, Gutierrez-Arcelus M, Smith KS, Kukurba KR, Zhang R, Eng C, Torgerson DG, Urbanek C; GTEx Consortium, Li JB, Rodriguez-Santana JR, Burchard EG, Seibold MA, MacArthur DG, Montgomery SB, Zaitlen NA, Lappalainen T.

Genome Res. 2015 Jul;25(7):927-36

Genetic ancestry in lung-function predictions

Kumar R, Seibold MA, Aldrich MC, Williams LK, Reiner AP, Colangelo L, Galanter J, Gignoux C, Hu D, Sen S, Choudhry S, Peterson EL, Rodriguez-Santana J, Rodriguez-Cintron W, Nalls MA, Leak TS, O'Meara E, Meibohm B, Kritchevsky SB, Li R, Harris TB, Nickerson DA, Fornage M, Enright P, Ziv E, Smith LJ, Liu K, Burchard EG.

N Engl J Med. 2010 Jul 22;363(4):321-30. doi: 10.1056/NEJMoa0907897. Epub 2010 Jul 7.

ASTHMA METAGENOMICS AND ENVIRONMENTAL RISK FACTORS

 

Dual RNA-seq reveals viral infections in asthmatic children without respiratory illness which are associated with changes in the airway transcriptome

Wesolowska-Andersen A, Everman JL, Davidson R, Rios C, Herrin R, Eng C, Janssen WJ, Liu AH, Oh SS, Kumar R, Fingerlin TE, Rodriguez-Santana J, Burchard EG, Seibold MA.

Genome Biol. 2017 Jan 19;18(1):12. 

Differential methylation between ethnic sub-groups reflects the effect of genetic ancestry and environmental exposures

Galanter JM, Gignoux CR, Oh SS, Torgerson D, Pino-Yanes M, Thakur N, Eng C, Hu D, Huntsman S, Farber HJ, Avila PC, Brigino-Buenaventura E, LeNoir MA, Meade K, Serebrisky D, Rodríguez-Cintrón W, Kumar R, Rodríguez-Santana JR, Seibold MA, Borrell LN, Burchard EG, Zaitlen N.

Elife. 2017 Jan 3;6.

Air Pollution and Lung Function in Minority Youth with Asthma in the GALA II (Genes-Environments and Admixture in Latino Americans) and SAGE II (Study of African Americans, Asthma, Genes, and Environments) Studies

Neophytou AM, White MJ, Oh SS, Thakur N, Galanter JM, Nishimura KK, Pino-Yanes M, Torgerson DG, Gignoux CR, Eng C, Nguyen EA, Hu D, Mak AC, Kumar R, Seibold MA, Davis A, Farber HJ, Meade K, Avila PC, Serebrisky D, Lenoir MA, Brigino-Buenaventura E, Rodriguez-Cintron W, Bibbins Domingo K, Thyne SM, Williams LK, Sen S, Gilliland FD, Gauderman WJ, Rodriguez-Santana JR, Lurmann F, Balmes JR, Eisen EA, Burchard EG.

Am J Respir Crit Care Med. 2016 Jun 1;193(11):1271-80.

AIRWAY EPITHELIAL BIOLOGY AND GENE EDITING

 

Primary Airway Epithelial Cell Gene Editing Using CRISPR-Cas9.

Everman JL, Rios C, Seibold MA.

Methods Mol Biol. 2018;1706:267-292. doi: 10.1007/978-1-4939-7471-9_15.

CRISPR-Cas9-mediated gene knockout in primary human airway epithelial cells reveals a proinflammatory role for MUC18

Chu HW, Rios C, Huang C, Wesolowska-Andersen A, Burchard EG, O'Connor BP,Fingerlin TE, Nichols D, Reynolds SD, Seibold MA.

Gene Ther. 2015 Oct;22(10):822-9.

Airway Progenitor Clone Formation Is Enhanced by Y-27632-Dependent Changes in the Transcriptome

Reynolds SD, Rios C, Wesolowska-Andersen A, Zhuang Y, Pinter M, Happoldt C, Hill CL, Lallier SW, Cosgrove GP, Solomon GM, Nichols DP, Seibold MA.

Am J Respir Cell Mol Biol. 2016 Sep;55(3):323-36.

ATOPIC DERMATITIS

 

Minimally invasive skin tape strip RNA sequencing identifies novel characteristics of the type 2-high atopic dermatitis disease endotype

Dyjack NGoleva ERios CKim BEBin LTaylor PBronchick C2, Hall CFRichers BNSeibold MALeung DYM.

J Allergy Clin Immunol. 2018 Apr;141(4):1298-1309

Lipid abnormalities in atopic skin are driven by type 2 cytokines

Berdyshev E, Goleva E, Bronova I, Dyjack N, Rios C, Jung J, Taylor P, Jeong M, Hall CF, Richers BN, Norquest KA, Zheng T, Seibold MA, Leung DY.

JCI Insight. 2018 Feb 22;3(4). pii: 98006. doi: 10.1172/jci.insight.98006. [Epub ahead of print]

 

IDIOPATHIC PULMONARY FIBROSIS

The idiopathic pulmonary fibrosis honeycomb cyst contains a mucocilary pseudostratified epithelium

Seibold MA, Smith RW, Urbanek C, Groshong SD, Cosgrove GP, Brown KK, Schwarz MI, Schwartz DA, Reynolds SD.

PLoS One. 2013;8(3):e58658.

A common MUC5B promoter polymorphism and pulmonary fibrosis

Seibold MA, Wise AL, Speer MC, Steele MP, Brown KK, Loyd JE, Fingerlin TE, Zhang W, Gudmundsson G, Groshong SD, Evans CM, Garantziotis S, Adler KB, Dickey BF, du Bois RM, Yang IV, Herron A, Kervitsky D, Talbert JL, Markin C, Park J, Crews AL, Slifer SH, Auerbach S, Roy MG, Lin J, Hennessy CE, Schwarz MI, Schwartz DA.

N Engl J Med. 2011 Apr 21;364(16):1503-12. doi: 10.1056/NEJMoa1013660.

SELECT REVIEWS

Interleukin-13 Stimulation Reveals the Cellular and Functional Plasticity of the Airway Epithelium

Seibold MA.

Ann Am Thorac Soc. 2018 Apr;15

Airway molecular endotypes of asthma: dissecting the heterogeneity

Wesolowska-Andersen A, Seibold MA.

Curr Opin Allergy Clin Immunol. 2015 Apr;15(2):163-8. 

The lung: the natural boundary between nature and nurture

Seibold MA, Schwartz DA.

Annu Rev Physiol. 2011;73:457-78. 

LINK TO ALL PUBLICATIONS

http://www.ncbi.nlm.nih.gov/sites/myncbi/max.seibold.1/bibliography/48045361/public/?sort=date&direction=ascending

Seibold Laboratory

The Seibold Lab publishes high impact original research in a wide range of genetic/genomic, clinical, cell biological, and translational scientific journals.  

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© Seibold Lab 2018